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CBD for Anxiety: A Survey of Current Research

Our bodies are hard-wired to survive. Anxiety and fear are natural responses to people, places, and things that are threats to our survival. In and of themselves, these responses are not bad. But, what are known as anxiety disorders may be present when such feelings are excessive, persistent, and present without good reason. The pharmaceutical industry has developed a number of effective medicines, but they have a very high risk of abuse potential and can come with unwanted Side effects. Especially benzos like Xanax and SSRI antidepressants.

Fortunately for those who would like to stay clear of such mind altering and psychoactive chemicals, scientific studies and customer testimonials around the world have shown that CBD has a lot of promise as a safe and natural alternative remedy for anxiety-related disorders.

This would make CBD a potential alternative to currently prescribed medicines, which have been shown to cause considerable side effects, while being ineffective.

 

What is General Anxiety Disorder?

Generalized anxiety disorder (GAD) is when someone is in a continual state of worry, fear and dread, day in and day out. It is estimated that up 2% of the European population, or 15 million people, are affected with some form of GAD. An even greater number of people feel milder, and less consistent, forms of anxiety that still negatively affect their lives.

GAD will often make it difficult for those affected to do basic activities like going to school or work. It also can seriously affect one’s ability and desire to socialize and can damage personal relationships. 

 

The Endocannabinoid System and Anxiety

Your endocannabinoid system is a complex system of chemicals and receptors throughout your body in charge of regulating various functions like sleep, mood, appetite, memory, reproduction, fertility and more. The endocannabinoid system also plays a role in the regulation of anxiety-related disorders.

Within the ECS, one endocannabinoid called anandamide, also known as the ‘bliss molecule’, works to regulate your emotions and is responsible for coordinating the reward system in your body that stimulates a sense of happiness and mental wellbeing.

Anandamide has also been recognized as a troubleshooter for a number of functions within your body, such as inflammation, pain, mood, and appetite.

 

So How Does CBD help with anxiety?

So, when you’re using CBD, your body processes more anandamide rather than breaking it down, thus making its effects even stronger. In other words, CBD plays a role in making the endocannabinoid anandamide more effective, thus having a positive impact on mood regulation.  

So when you’re experiencing anxiety, CBD can help your body regulate your emotions by interacting with your Endocannabinoid System. In addition, when CBD is used as a direct response to a stressor, it can relieve some of the physical symptoms caused by stress & anxiety, like increased heart rate and blood pressure.

 

Conclusion

More research needs to be done to have a conclusive and complete understanding of what exactly CBD can do for anxiety disorders.However, we do know now that CBD helps with physical and mental symptoms of anxiety by increasing the sensitivity of receptors throughout your body to endocannabinoids. By targeting the ECS with external cannabinoids, like CBD, it is possible to feel relief from anxiety related symptoms.

Sources

  1.     Blessing EM, Steenkamp MM, Manzanares J, Marmar CR. Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics. 2015;12(4):825-836. doi:10.1007/s13311-015-0387-1
  2.     Haj-Dahmane S, Shen RY. Modulation of the serotonin system by endocannabinoid signaling. Neuropharmacology. 2011;61(3):414-420. doi:10.1016/j.neuropharm.2011.02.016
  3.   Jadoon KA, Tan GD, O’Sullivan SE. A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study. JCI Insight. 2017;2(12):e93760. Published 2017 Jun 15. doi:10.1172/jci.insight.93760
  4.   Leweke FM, Piomelli D, Pahlisch F, et al. Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Transl Psychiatry. 2012;2(3):e94. Published 2012 Mar 20. doi:10.1038/tp.2012.15
  5.   Papagianni EP, Stevenson CW. Cannabinoid Regulation of Fear and Anxiety: an Update. Curr Psychiatry Rep. 2019;21(6):38. Published 2019 Apr 27. doi:10.1007/s11920-019-1026-z
  6.   Stanley CP, Hind WH, O’Sullivan SE. Is the cardiovascular system a therapeutic target for cannabidiol?. Br J Clin Pharmacol. 2013;75(2):313-322. doi:10.1111/j.1365-2125.2012.04351.x
  7.  Wright M, Di Ciano P, Brands B. Use of Cannabidiol for the Treatment of Anxiety: A Short Synthesis of Pre-Clinical and Clinical Evidence. Cannabis Cannabinoid Res. 2020;5(3):191-196. Published 2020 Sep 2. doi:10.1089/can.2019.0052